EcoliNet: a network by integration of all data-type-specific networks (CC, CX, DC, GN, HT, LC, PG)

Integrated network #genes #links
EcoliNet v.1 4099 genes 95520 links

Positive goldstandard co-functional gene pairs

Positive goldstandard co-functional gene pairs #genes #links
Co-functional gene pairs by GO-BP or EcoCyc annotations 1835 genes 10804 links
Co-functional gene pairs by GO-BP annotations 1474 genes 6896 links
Co-functional gene pairs by EcoCyc annotations 885 genes 4694 links

Integrated networks for each of data types

Data type #links Description
CC 50528 Inferred links by co-citation of two genes across 57,062 PubMed Central articles for E. coli biology (based on high-dimensional gene expression data)
CX 67494 Inferred links by co-expression pattern of two genes (based on high-dimensional gene expression data)
DC 9643 Inferred links by co-occurrence of protein domains between two coding genes
GN 23439 Inferred links by similar genomic context of bacterial orthologs of two E. coli genes
HT 15543 Inferred Links by high-throughput protein-protein interactions
LC 1073 Inferred Links by small/medium-scale protein-protein interactions (collected from protein-protein interaction data bases)
PG 17504 Inferred links by similar phylogenetic profiles between two E. coli genes

CX networks based on individual expression data sets (GEO series)

DB/data set Reference (PMID) Edge list download #link Experiment description
GSE7 11027315 download 36200 Tryptophan metabolism response in E. coli
GSE1106 15129285 download 30071 aerobic knock-out
GSE1107 18828895 download 26500 anaerobic knock-out
GSE1730 15535862 download 5096 mRNA abundance from wild type
GSE1780 15817786 download 8892 The expression profile of Escherichia coli K-12 in response to minimal, optimal and excess copper concentrations
GSE2999 NA download 27495 Cisplatin-induced gene expression in DNA adenine methyltransferase (dam) and mismatch repair deficient E. coli
GSE3250 16141204 download 12037 BW25113 glucose to acetate transition
GSE3591 17921306 download 8972 A reassesment of the FNR regulon and the effects of nitrate,nitrite, narXL and narQP
GSE3905 17222132 download 7002 Temporal Biofilm Expression of E. coli K-12 after 4, 7, 15, and 24 hr
GSE3977 14981237 download 19197 Comparative Transcript Abundance in E. Coli Degradosome Mutants and their Parental Strains
GSE4363 16626502 download 19004 Recovery from stationary phase in LB + 0.2 % glucose
GSE4408 17009874 download 11070 Transcriptional consequences of DNA gyrase inhibition
GSE4511 15601715 download 12005 pH Regulates Genes for Flagellar Motility, Catabolism, and Oxidative Stress in Escherichia coli K-12
GSE6033 20863252 download 15203 Reference Design time-course
GSE6836 17214507 download 14450 Large-Scale Mapping and Validation of E. coli Transcriptional Regulation from a Compendium of Expression Profiles
GSE7326 19304752 download 5241 Expression profiles during cell death programmed by a restriction-modification system in E. coli
GSE7398 17768236 download 12927 Expression data from E. coli covering four phases of growth in Fis KO and WT (Fis+) strains
GSE7477 NA download 19717 Global transcriptional response of Escherichia coli O157:H7 to growth transitions in glucose minimal medium
GSE7573 17494765 download 13948 Identification of NO Response Network in E. coli
GSE7885 17979199 download 25060 Gene expression of E. coli MG1655 wild type and rpoS knock-out strains
GSE9923 18528414 download 17890 Indole cell signaling occurs primarily at low temperatures in Escherichia coli
GSE10158 18192383 download 7079 Expression of Escherichia coli treated with cefsulodin and mecillinam, alone and in combination
GSE10855 18467556 download 23988 MG1655 temperature O2 response normalized data Tavazoie
GSE11041 19767843 download 19800 Overlapping and unique responses of E. coli to adverse conditions
GSE11087 18430135 download 10970 E. coli Isoleucine starvation and stringent response network
GSE11183 19194530 download 13890 Identification of the Escherichia coli HU regulon
GSE12797 18843507 download 13907 Control of RpoS in global gene expression of Escherichia coli in minimal media
GSE12877 19091747 download 12032 Transcriptional profiling of Escherichia coli after addition of CO-RMs to aerobically growing cells
GSE13048 19091747 download 18914 Transcriptional profiling of Escherichia coli
GSE13418 19376922 download 30611 Gene expression of E. coli MG1655 at attachment, colony formation and maturation during biofilm formation
GSE13444 19536200 download 38923 Identification of isobutanol response network of E. coli
GSE13666 19798444 download 24763 Evolution of E. coli transcriptome under osmotic-stress with and without RpoS
GSE15405 20008510 download 90421 Expression data from E. coli cells overexpressing GraL for long periods of time
GSE15406 20008510 download 41684 Expression data from E. coli cells overexpressing GraL for short and long periods of time
GSE15409 19366454 download 14828 Amino acid/Nucleotide perturbation in Escherichia coli
GSE15500 21057108 download 10003 Analysis of differences in gene expression due to small adaptive mutations in RNA polymerase B' subunit (rpoC)
GSE16973 20118358 download 3492 Functional Genomic Study of Exogenous n-Butanol Stress in Escherichia coli
GSE17276 19893610 download 39945 Transcriptional profiling of an evolved polymorphism in E. coli
GSE17584 19703305 download 12225 Transcriptional effects of CRP* expression in Escherichia coli
GSE19742 20478253 download 13966 Expression profiling of E.coli K-12 wild-type vs. delta dksA cells upon amino acid starvation
GSE20305 20461071 download 31877 Time resolved response of E. coli to 5 different stress conditions
GSE21839 20709841 download 16926 Transcriptome analysis of wild type E. coli (K-12 MG1655) comparing to mutant E. coli strain (ECOM4) under aerobic and anaerobic conditions
GSE21869 21785135 download 15320 Expression profiles of evolved clones isolated at various stages during adaptive experimental evolution of E. coli
GSE26187 22016571 download 13001 Transcriptional profiling of Escherichia coli during a transition from zinc starvation to surfeit
GSE28412 22018139 download 7004 Analyzing the metabolic stress response of recombinant Escherichia coli cultures expressing human interferon beta in high cell density fed batch cultures using time course transcriptomic data
GSE28795 22056927 download 9926 Expression data from E. coli cells overexpressing either GreA or GreB in ppGpp0 cells in the dksA+ or dksA- background
GSE29424 21948837 download 5921 Functional genomics study of endogenous free fatty acid overproduction in Escherichia coli
GSE30639 22645336 download 8910 Evolution of gene expression during long term coexistence in a bacterial evolution experiment
GSE31333 16249312 download 29958 NIA Neuroarray dehydration
GSE32561 22038610 download 18815 Investigating the impact of heterologous expression of the Micrococcus luteus FabH on global transcription in Escherichia coli
GSE32562 22122981 download 13089 Trimethoprim response in Escherichia coli in bacteriostatic and bactericidal conditions
GSE33147 16204189 download 32077 Expression data from laboratory evolution of Escherichia coli on lactate or glycerol
GSE34023 22295907 download 21682 Overexpression of BglJ and LeuO in Escherichia coli K12
GSE35049 22389370 download 41839 Analysis of ethanologenic E. coli strain GLBRCE1 during fermentation of alkaline-pretreated corn stover hydrolysate

HT networks based on individual high-throughput protein-protein interaction data sets

Reference (PMID) Edge list download #link Experiment description
15690043 download 3446 Large-scale APMS (Butland et al. Nature 2005)
16606699 download 6483 Genome-scale APMS (Arifuzzaman et al. Genome Res. 2006)
19402753 download 5959 Large-scale APMS (Hu et al. PLoS Biol. 2009)
24561554 download 1106 Large-scale yeast two-hybrid (Y2H) screen (Rajagopala et al. Nat Biotechnol. 2014)


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