1. If there exists any related human disease or biological process to the input model organism gene list based on evolutionary conserved pathways, or to assess the relevance of the input pathway as an appropriate model to study a target human disease.
2. If novel human disease gene candidates derived from the input model organisms pathway are functionally coupled in the gene network to the known disease genes.
1. It explicitly overlays model organism pathways on a human gene network.
2. It searches for related human diseases with high sensitivity by using a network-based gene set association algorithm, RIDDLE.
3. It can visualize the resulting disease gene networks incorporating novel disease gene candidates from the model organism studies.
1. Human orthologs for the submitted query genes of model organisms
2. Significantly related human diseases or biological processes to the input gene list
3. Prioritized input query genes for each disease pathways
4. A network of disease genes and input query genes
See the Tutorial page for the detailed descriptions.
|Algorithm||Gene set database|
|Fisher's Exact Test||OMIM, Disease Ontology, GWAS catalog, Genetic Association Database, GO biological process, KEGG pathway|
MORPHIN: a web tool for human disease research by projecting model organisms on a human integrated gene network Sohyun Hwang, Eiru Kim, Sunmo Yang, Edward M. Marcotte, and Insuk Lee, Nucl. Acids Res. (2014) First published online: May 26, 2014
This work was supported by the National Research Foundation of Korea grant (2010-0017649, 2012M3A9B4028641, 2012M3A9C7050151).