Step 1. Select a network for your analysis.
HumanNet-PI (Protein-protein Interaction network)
HumanNet-FN (Functional gene network)
HumanNet-XC (Functional gene network extended by Co-citation)
Step 2. Select your analysis.
Network-based disease gene prediction
You may predict novel candidate genes for diseases (or biological processes) of your interest.
Submit
'guide genes'
that are known to be involved in the disease.
Server will prioritize genes as novel candidates for the disease by closeness to the guide genes in the network.
You will be able to explore the putative disease gene network with an interactive network viewer.
Network-based disease annotation prediction
You may predict disease (or biological process) annotations for your gene(s) of interest.
Server will prioritize annotation terms by enrichment of those transferred from all neighbor genes in the network.
You will see prioritized terms of DisGeNET, DISEASES,
HPO
, and
GOBP
for your query gene.
Step 3. Submit Guide Genes.
Please submit
Entrez Gene ID
or
Official Symbol
of guide gene(s).
The number of guide genes should be less than 200.
For less than 4 guide genes, ROC and within-group connectivity analyses will not be not provided.
Each gene should be separated by comma, tab, white space, or new line.
Submit 43 COVID-19 GWAS genes
(Case study gene set on the paper)
You can also select guide genes from pre-defined gene sets. We provide disease genes from the DISEASES, DisGeNET,
HPO
, and GWAS catalog databases.
Select guide genes from the pre-defined gene sets
Proceed Candidate Gene Prediction
Step 3. Submit Query Genes.
Please submit
Entrez Gene ID
or
Official Symbol
of query genes.
We recommend you submit no more than 20 genes per query.
Each gene should be separated by comma, tab, white space, or new line.
Example genes
Proceed Gene Annotation Prediction
HumanNet Team
Network Biomedicine Lab, Yonsei University.
Marcotte Lab, University of Texas at Austin.
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Predefined Gene Sets
Select guide genes from the pre-defined gene sets.
Listed terms have 4 or more genes.
Selected genes
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