Integrated Networks

Network Description # Genes
(Genome coverage)
# Links
HumanNet-XN Fully extended functional gene network 17,929 (95.3%) 525,537
HumanNet-XC Functional gene network extended by co-citation 17,790 (94.6%) 424,501
HumanNet-XI Functional gene network extended by interolog 17,303 (92.0%) 418,525
HumanNet-FN Functional gene network 17,247 (91.7%) 371,502
HumanNet-CF Co-functional network 14,739 (78.4%) 252,590
HumanNet-PI Protein-protein interaction network 15,352 (81.6%) 158,499

Component Networks

Network Description # Genes # Links
CC Co-functional links by co-citation 10,303 72,819
CE Co-functional links by co-essentiality 4,052 71,243
CX Co-functional links by co-expression 6,658 29,481
DB Co-functional links by pathway database 7,512 125,550
DP Co-functional links by protein domain profile associations 9,454 45,958
GN Co-functional links by gene neighborhood 2,403 24,862
HT Protein-protein interactions by high throughput assays 12,641 78,627
IL Protein-protein interactions transferred from model organisms 9,077 113,499
LC Literature-curated protein-protein interactions 13,790 122,444
PG Co-functional links by phylogenetic profile associations 1,552 10,888

Protein-protein interaction networks derived from non-human organisms (interologs)

Network Description # Genes # Links
CE-HT High-throughput PPI in C. elegans 868 1,041
CE-LC Literature-curated PPI in C. elegans 575 860
DM-HT High-throughput PPI in D. melanogaster 3,912 6,383
DM-LC Literature-curated PPI in D. melanogaster 1,299 3,196
DR-LC Literature-curated PPI in D. rerio 169 179
MM-LC Literature-curated PPI in M. musculus 5,120 11,336
SC-GT Genetic interactions in S. cerevisiae 2,671 44,222
SC-HT High-throughput PPI in S. cerevisiae 2,326 39,536
SC-LC Literature-curated PPI in S. cerevisiae 2,580 23,974
SC-TS Protein 3D structure based interactions in S. cerevisiae 857 6,005
CLF-LC Literature-curated PPI in C. l. familiaris 9 5
BT-LC Literature-curated PPI in B. taurus 275 2,230
RN-LC Literature-curated PPI in Rattus norvegicus 1,129 5,135
GG-LC Literature-curated PPI in Gallus gallus 123 1,000

HumanNet Team
Network Biomedicine Lab, Yonsei University.
Marcotte Lab, University of Texas at Austin.
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